施工実績

Although not, the general research try unconvincing. Small size and you may useless weight reduction comparison are some of the restrictions out-of the earlier epidemiological degree, because diet plan centered on one twenty-four-hour keep in mind was applied to help you expect coronary arrest frequency more than a twelve-, 1 16-, 2 otherwise 20-season months. 4 This fat loss testing decreases the capability to to improve to have use off other foods otherwise nutrients that will give an explanation for inverse connections said. eleven To get over that it limitation, i addressed new theory you to high potassium consumption reduces the exposure away from heart attack inside the a big cohort of males just who accomplished an effective detailed and you may verified semiquantitative restaurants frequency survey during the baseline and you will was indeed then followed upwards getting 8 ages. At the same time, i checked-out new connectivity between likelihood of stroke and you will consumption out of fibre, magnesium, and you will calcium, which are synchronised that have intake regarding potassium and might feel related so you can threat of coronary arrest.

Inhabitants

The Health Professionals Follow-up Study began in 1986, when 51 529 health professionals 40 to 75 years old 12 completed a 131-item food-frequency questionnaire and provided information about medical history and lifestyle. Follow-up questionnaires were sent every 2 years to update information on potential risk factors and to identify newly diagnosed cases of stroke and other diseases. We excluded from analysis 1595 men who did not satisfy the a priori criteria of daily caloric intake between 800 and 4200 kcal and <70 blanks out of 131 total listed food items. In addition, we excluded men with prior diagnosis of myocardial infarction, angina, coronary artery surgery, stroke, transient ischemic attack, peripheral arterial disease, or diabetes. The average response rate for the 2-year follow-up cycles was >94%. Nonresponding participants not matched to the National Death Index were assumed to be alive.

Research away from Dieting and Most other Coverage Variables

Brand new 1986 survey inquired about average regularity regarding consumption from inside the early in the day season away from specified portions out-of 131 delicacies and employ regarding vitamin and mineral products. Nutrient computations took under consideration this form of morning meal cereal and multivitamins said from the for every single topic. I together with asked about the means to access specific medications out-of potassium and you can magnesium (besides multivitamins). We thought the degree of potassium on these particular medicine to feel step one grams/d which out of magnesium 0.3 grams/d, just like the information on dosages weren’t expected in the survey. I assessed the newest legitimacy of the survey in a random test out of 127 people whom complete a couple of step one-week diet plan records. thirteen The fresh correlations involving the 2 assessments off intake, energy-modified and you may fixed to have inside-people adaptation in the diet facts, was basically 0.65 to own potassium, 0.64 having fiber, 0.66 for magnesium, and you may 0.53 getting calcium. Including eating plan, from inside the 1986, members were questioned so you can statement their typical systolic and diastolic blood stress and you may whether or not they got medical practitioner-diagnosed blood pressure level. Brand new authenticity of them parameters could have been recorded in earlier times. fourteen

Times

Avoid facts was in fact deadly and you may nonfatal shots occurring within go back of baseline questionnaire and January 29, 1994. People revealing an instance heart attack to the a take-up survey have been requested consent to examine medical facts. Shots was in fact confirmed if the described as a frequent neurologic problem out of abrupt otherwise rapid beginning, long-lasting ?a day and you may due to a great cerebrovascular event. Strokes considering issues otherwise neoplasia have been omitted. Studies was conducted of the doctors with no knowledge of this new subjects’ exposure factor condition. Shots was in fact subclassified with respect to the conditions of one’s National Survey away from Heart attack due to the fact on account of ischemia (embolism or thrombosis), subarachnoid hemorrhage, intracerebral hemorrhage, or unknown produce. fifteen In the event that zero details could well be received, strokes was basically experienced possible once they called for hospitalization and was basically corroborated of the more information provided with letter otherwise interview.